(Fortune) — 1. Wal-Mart Stores
Rank: 1 (Previous rank: 2)
CEO: Michael T. Duke
Compare tool: Wal-Mart vs. Top 10
The mega-retailer didn’t have a whole lot to complain about in fiscal 2010. Profits were up and, thanks to its sales, the company once again climbed to the top of the Fortune 500.